Prevention of preterm birth: harnessing science to address the global epidemic.
Identifieur interne : 001963 ( Main/Exploration ); précédent : 001962; suivant : 001964Prevention of preterm birth: harnessing science to address the global epidemic.
Auteurs : Craig E. Rubens [États-Unis] ; Yoel Sadovsky [États-Unis] ; Louis Muglia [États-Unis] ; Michael G. Gravett [États-Unis] ; Eve Lackritz [États-Unis] ; Courtney Gravett [États-Unis]Source :
- Science translational medicine [ 1946-6242 ] ; 2014.
Descripteurs français
- KwdFr :
- Accouchement prématuré (), Accouchement prématuré (physiopathologie), Animaux, Facteurs de risque, Femelle, Grossesse, Humains, Modèles biologiques, Naissance prématurée (), Naissance prématurée (physiopathologie), Naissance à terme, Nouveau-né, Prise en charge prénatale, Prématuré, Périnatologie, Recherche médicale translationnelle, Souris, Utérus (métabolisme).
- MESH :
- métabolisme : Utérus.
- physiopathologie : Accouchement prématuré, Naissance prématurée.
- Accouchement prématuré, Animaux, Facteurs de risque, Femelle, Grossesse, Humains, Modèles biologiques, Naissance prématurée, Naissance à terme, Nouveau-né, Prise en charge prénatale, Prématuré, Périnatologie, Recherche médicale translationnelle, Souris.
English descriptors
- KwdEn :
- Animals, Female, Humans, Infant, Newborn, Infant, Premature, Mice, Models, Biological, Obstetric Labor, Premature (physiopathology), Obstetric Labor, Premature (prevention & control), Perinatology, Pregnancy, Premature Birth (physiopathology), Premature Birth (prevention & control), Prenatal Care, Risk Factors, Term Birth, Translational Medical Research, Uterus (metabolism).
- MESH :
- metabolism : Uterus.
- physiopathology : Obstetric Labor, Premature, Premature Birth.
- prevention & control : Obstetric Labor, Premature, Premature Birth.
- Animals, Female, Humans, Infant, Newborn, Infant, Premature, Mice, Models, Biological, Perinatology, Pregnancy, Prenatal Care, Risk Factors, Term Birth, Translational Medical Research.
Abstract
Preterm birth is a leading cause of infant morbidity and mortality worldwide, but current interventions to prevent prematurity are largely ineffective. Preterm birth is increasingly recognized as an outcome that can result from a variety of pathological processes. Despite current research efforts, the mechanisms underlying these processes remain poorly understood and are influenced by a range of biological and environmental factors. Research with modern techniques is needed to understand the mechanisms responsible for preterm labor and birth and identify targets for diagnostic and therapeutic solutions. This review evaluates the state of reproductive science relevant to understanding the causes of preterm birth, identifies potential targets for prevention, and outlines challenges and opportunities for translating research findings into effective interventions.
DOI: 10.1126/scitranslmed.3009871
PubMed: 25391484
Affiliations:
- États-Unis
- Ohio, Pennsylvanie, Washington (État)
- Pittsburgh, Seattle
- Université de Pittsburgh, Université de Washington
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Le document en format XML
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Rubens</name><affiliation wicri:level="2"><nlm:affiliation>Global Alliance to Prevent Prematurity and Stillbirth, Seattle Children's Hospital, Seattle, WA 98101, USA. craig.rubens@seattlechildrens.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Alliance to Prevent Prematurity and Stillbirth, Seattle Children's Hospital, Seattle, WA 98101</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Sadovsky, Yoel" sort="Sadovsky, Yoel" uniqKey="Sadovsky Y" first="Yoel" last="Sadovsky">Yoel Sadovsky</name><affiliation wicri:level="4"><nlm:affiliation>Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, PA 15213, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, PA 15213</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Muglia, Louis" sort="Muglia, Louis" uniqKey="Muglia L" first="Louis" last="Muglia">Louis Muglia</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Perinatal Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Perinatal Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45229</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Gravett, Michael G" sort="Gravett, Michael G" uniqKey="Gravett M" first="Michael G" last="Gravett">Michael G. Gravett</name><affiliation wicri:level="4"><nlm:affiliation>Global Alliance to Prevent Prematurity and Stillbirth, Seattle Children's Hospital, Seattle, WA 98101, USA. Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Alliance to Prevent Prematurity and Stillbirth, Seattle Children's Hospital, Seattle, WA 98101, USA. Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Lackritz, Eve" sort="Lackritz, Eve" uniqKey="Lackritz E" first="Eve" last="Lackritz">Eve Lackritz</name><affiliation wicri:level="2"><nlm:affiliation>Global Alliance to Prevent Prematurity and Stillbirth, Seattle Children's Hospital, Seattle, WA 98101, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Alliance to Prevent Prematurity and Stillbirth, Seattle Children's Hospital, Seattle, WA 98101</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Gravett, Courtney" sort="Gravett, Courtney" uniqKey="Gravett C" first="Courtney" last="Gravett">Courtney Gravett</name><affiliation wicri:level="2"><nlm:affiliation>Global Alliance to Prevent Prematurity and Stillbirth, Seattle Children's Hospital, Seattle, WA 98101, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Alliance to Prevent Prematurity and Stillbirth, Seattle Children's Hospital, Seattle, WA 98101</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author></analytic><series><title level="j">Science translational medicine</title><idno type="eISSN">1946-6242</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Female</term><term>Humans</term><term>Infant, Newborn</term><term>Infant, Premature</term><term>Mice</term><term>Models, Biological</term><term>Obstetric Labor, Premature (physiopathology)</term><term>Obstetric Labor, Premature (prevention & control)</term><term>Perinatology</term><term>Pregnancy</term><term>Premature Birth (physiopathology)</term><term>Premature Birth (prevention & control)</term><term>Prenatal Care</term><term>Risk Factors</term><term>Term Birth</term><term>Translational Medical Research</term><term>Uterus (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Accouchement prématuré ()</term><term>Accouchement prématuré (physiopathologie)</term><term>Animaux</term><term>Facteurs de risque</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Modèles biologiques</term><term>Naissance prématurée ()</term><term>Naissance prématurée (physiopathologie)</term><term>Naissance à terme</term><term>Nouveau-né</term><term>Prise en charge prénatale</term><term>Prématuré</term><term>Périnatologie</term><term>Recherche médicale translationnelle</term><term>Souris</term><term>Utérus (métabolisme)</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Uterus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Utérus</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Accouchement prématuré</term><term>Naissance prématurée</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Obstetric Labor, Premature</term><term>Premature Birth</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Obstetric Labor, Premature</term><term>Premature Birth</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Humans</term><term>Infant, Newborn</term><term>Infant, Premature</term><term>Mice</term><term>Models, Biological</term><term>Perinatology</term><term>Pregnancy</term><term>Prenatal Care</term><term>Risk Factors</term><term>Term Birth</term><term>Translational Medical Research</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Accouchement prématuré</term><term>Animaux</term><term>Facteurs de risque</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Modèles biologiques</term><term>Naissance prématurée</term><term>Naissance à terme</term><term>Nouveau-né</term><term>Prise en charge prénatale</term><term>Prématuré</term><term>Périnatologie</term><term>Recherche médicale translationnelle</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Preterm birth is a leading cause of infant morbidity and mortality worldwide, but current interventions to prevent prematurity are largely ineffective. Preterm birth is increasingly recognized as an outcome that can result from a variety of pathological processes. Despite current research efforts, the mechanisms underlying these processes remain poorly understood and are influenced by a range of biological and environmental factors. Research with modern techniques is needed to understand the mechanisms responsible for preterm labor and birth and identify targets for diagnostic and therapeutic solutions. This review evaluates the state of reproductive science relevant to understanding the causes of preterm birth, identifies potential targets for prevention, and outlines challenges and opportunities for translating research findings into effective interventions.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li><li>Pennsylvanie</li><li>Washington (État)</li></region><settlement><li>Pittsburgh</li><li>Seattle</li></settlement><orgName><li>Université de Pittsburgh</li><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Rubens, Craig E" sort="Rubens, Craig E" uniqKey="Rubens C" first="Craig E" last="Rubens">Craig E. Rubens</name></region><name sortKey="Gravett, Courtney" sort="Gravett, Courtney" uniqKey="Gravett C" first="Courtney" last="Gravett">Courtney Gravett</name><name sortKey="Gravett, Michael G" sort="Gravett, Michael G" uniqKey="Gravett M" first="Michael G" last="Gravett">Michael G. Gravett</name><name sortKey="Lackritz, Eve" sort="Lackritz, Eve" uniqKey="Lackritz E" first="Eve" last="Lackritz">Eve Lackritz</name><name sortKey="Muglia, Louis" sort="Muglia, Louis" uniqKey="Muglia L" first="Louis" last="Muglia">Louis Muglia</name><name sortKey="Sadovsky, Yoel" sort="Sadovsky, Yoel" uniqKey="Sadovsky Y" first="Yoel" last="Sadovsky">Yoel Sadovsky</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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